Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
Author :
Publisher : Frontiers Media SA
Total Pages : 111
Release :
ISBN-10 : 9782889454228
ISBN-13 : 2889454223
Rating : 4/5 (223 Downloads)

Book Synopsis Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy by : Patrizia Agostinis

Download or read book Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy written by Patrizia Agostinis and published by Frontiers Media SA. This book was released on 2018-02-19 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.


Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy Related Books

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
Language: en
Pages: 111
Authors: Patrizia Agostinis
Categories:
Type: BOOK - Published: 2018-02-19 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigen
Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
Language: en
Pages: 0
Authors:
Categories:
Type: BOOK - Published: 2018 - Publisher:

DOWNLOAD EBOOK

Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigen
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Language: en
Pages: 622
Authors: M. A. Hayat
Categories: Medical
Type: BOOK - Published: 2017-09-07 - Publisher: Academic Press

DOWNLOAD EBOOK

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machiner
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Language: en
Pages: 430
Authors: M. A. Hayat
Categories: Medical
Type: BOOK - Published: 2016-12-28 - Publisher: Academic Press

DOWNLOAD EBOOK

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy
Autophagy and Cancer
Language: en
Pages: 261
Authors: Hong-Gang Wang
Categories: Medical
Type: BOOK - Published: 2013-03-30 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regu